IndraLab

Statements

Genome polyprotein inhibits KCNH2. 5 / 5
| 5
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"All this suggests that a presence of E2 can potentially enhance hERG block by dofetilide, and thus enhance its proclivity to promote arrhythmia."
28516454
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"Our results resemble the acute effects of 17β-estradiol (E2) in female guinea pig ventricular myocytes; it has been shown that physiological concentration of E2 acutely suppressed the hERG channel and prolonged APD in female guinea pig ventricular myocytes (Kurokawa et al., 2008)."
36584932
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"MD simulations suggest that E2 dissociates rapidly from this site in WT and hence is unlikely to impair function of WT hERG channel."
28516454
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"Experimental results XREF_BIBR shown in XREF_FIG (top) illustrate that E2 (1 nM) considerably increased the suppression of hERG by E-4031 (light gray line)."
20126530
reach
"Our current study reveals the first mechanistic models of how E2 could potentially enhance hERG blockade."
28516454