IndraLab

Statements

E2 inhibits KCNH2. 4 / 4
| 4
reach
"MD simulations suggest that E2 dissociates rapidly from this site in WT and hence is unlikely to impair function of WT hERG channel."
28516454
reach
"Experimental results XREF_BIBR shown in XREF_FIG (top) illustrate that E2 (1 nM) considerably increased the suppression of hERG by E-4031 (light gray line)."
20126530
reach
"All this suggests that a presence of E2 can potentially enhance hERG block by dofetilide, and thus enhance its proclivity to promote arrhythmia."
28516454
reach
"Our current study reveals the first mechanistic models of how E2 could potentially enhance hERG blockade."
28516454