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USP8 deubiquitinates FZR1. 5 / 5
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"Mechanistically, we showed that USP8 interacted with the Fizzy-related (Fzr) protein, a conserved master regulator of endoreplication, thereby deubiquitinating and stabilizing Fzr to modulate endoreplication."
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"Mechanistically, USP8 interacts with Fzr to deubiquitinate and stabilize Fzr."
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"USP8 deubiquitinates and stabilizes Fzr."
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"Notably, in vivo ubiquitination assays showed that USP8 depletion in the Bombyx PSGs and Drosophila salivary glands increased Fzr ubiquitination levels (Fig. 2, F and G, and fig."
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"Since proper folding of proteins generally devotes to their interactions with other partners (54), like the WD40 protein Bub3 (55), we thus suggest that the interaction of Hsp70 with Fzr facilitates proper folding of Fzr, thereby enhancing the interaction of Fzr with USP8 to promote Fzr deubiquitination and stabilization during endoreplication."
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