IndraLab

Statements

BAP1 activates homologous recombination. 5 / 5
| 5
reach
"Phosphorylation of BAP1 that promotes HR resulted in reduced chromatin binding of BAP1 ."
30559450
reach
"BAP1 deubiquitylates Ub-H2AK119 at sites of DNA damage, and the loss of BAP1 has been shown to impair homologous recombination (HR) repair (10)."
32206571
reach
"The function of UCHL1 in DSB repair is still unclear, but it has been established that UCHL5 promotes repair by enhancing DNA-end resection, whereas BAP1 promotes HR via an unknown mechanism ."
30559450
reach
"This suggests that deubiquitination of H2A by BAP1 promotes HR which is complementary to the finding that ubiquitination of K119 in response to DNA damage favors NHEJ [95]."
28624371
reach
"BAP1 loss impairs HR and double-strand break repair, promoting error-prone nonhomologous end joining, with consequent genomic instability (XREF_FIG)."
32690542