IndraLab

Statements

BAP1 activates homologous recombination. 9 / 9
| 9
reach
"Phosphorylation of BAP1 that promotes HR resulted in reduced chromatin binding of BAP1 ."
30559450
reach
"BAP1 deubiquitylates Ub-H2AK119 at sites of DNA damage, and the loss of BAP1 has been shown to impair homologous recombination (HR) repair (10)."
32206571
reach
"However, another study demonstrated that the E3 activity of BRCA1–BARD1 could be inhibited by BAP1, which mediates HR repair and confer radioresistance17."
37655321
reach
"This suggests that deubiquitination of H2A by BAP1 promotes HR which is complementary to the finding that ubiquitination of K119 in response to DNA damage favors NHEJ [95]."
28624371
reach
"BAP1 loss impairs HR and double-strand break repair, promoting error-prone nonhomologous end joining, with consequent genomic instability (XREF_FIG)."
32690542
reach
"BAP1 deficiency inhibits efficient HR repair and increases radiation sensitivity, suggesting that the deubiquitination of H2AK119ub promotes HR [78]."
35897775
reach
"The function of UCHL1 in DSB repair is still unclear, but it has been established that UCHL5 promotes repair by enhancing DNA-end resection, whereas BAP1 promotes HR via an unknown mechanism ."
30559450
reach
"Then, by using a GFP-based reporter assay, the authors showed that BAP1 promoted HR in a BRCA1-related pathway without exerting a significant impact on NHEJ."
37009801
reach
"Notably, the oncometabolite 2-hydroxyglutarate produced by mutant IDH1/2 enzymes, and loss of function of ARID1A, BAP1, or BRCA2 can impair the HR pathway, rendering cancer cells sensitive to PARPi treatment (18–21, 47, 48)."
36374558