IndraLab

Statements

USP2 activates cell population proliferation. 13 / 15
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"As shown in Fig. 5A and B, USP2 knockout significantly inhibited the proliferation of MM.1S and RPMI 8226 cell lines."
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"These results suggest that USP-2 promotes cell proliferation pertinent to the features of human hepatic and breast cancers."
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"For example, USP2, USP22, USP28, and USP37 stabilize c-Myc expression and, thus, stimulate the proliferation of many tumour cells [58–61] ."
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"The results of the Cell Counting Kit-8 and clone formation assays showed that ubiquitin-specific peptidase 2 knockdown enhanced the proliferation rate of 769-P, 786-O, and Caki-1 cells (Figures 2(g,h))."
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"This study highlighted that USP2 inhibition or knockdown could inhibit the proliferation of MM cells and induce MM cell apoptosis in vitro and in vivo."
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"USP2 overexpression promoted proliferation and metastasis, and induced the EMT in CM cells in vitro, while specific inhibition of USP2 by ML364 produced the opposite effects."
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"Mutations in the CYLD deubiquitinating enzyme leads to familial cylindromatosis XREF_BIBR and overexpression of USP2 has been reported to increase prostate cancer cell proliferation through the stabilization of fatty acid synthase XREF_BIBR."
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"In addition, USP2 inhibition suppressed CFs proliferation, collagen synthesis and cell cycle progression."
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"For example, USP2 and USP7 modulate p53 and MDM2, impacting cell survival and tumor development, while USP22 stabilizes c-Myc, driving cancer proliferation and metastasis [9–13]."
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"Taken together, these results strongly support that KRAS is a bona fide substrate of USP2.3.7 USP2 knockout inhibits the proliferation of MM cells."
39807309
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"USP2 promotes cell proliferation and metastasis in choroidal melanoma via stabilizing Snail."
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"These findings suggest an inhibitory role of USP2 in the proliferation of myeloid cells in the context of colon inflammation.It has been shown that USP2 promotes cell proliferation of bladder (Kim et al., 2012), prostate (Stevenson et al., 2007), pancreatic (Shi et al., 2011), and inhibits clear renal carcinoma cell lines proliferation (Meng et al., 2020)."
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"USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network."
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