IndraLab

Statements

USP46 activates LRP6. 3 / 3
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"These findings indicate that Arrow/LRP6 stabilization mediated by Usp46-dependent deubiquitylation is required for concentration-dependent responses in target cells, providing precision in signaling throughout the spatial range of the Wingless morphogen gradient."
37798281
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"These findings provide in vivo evidence that the Usp46 complex increases signaling strength by stabilizing Arrow/LRP6 and consequently promoting the cytoplasmic accumulation of Arm/β-catenin in Wingless-responding cells."
37798281
reach
"The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6."
37798281