IndraLab

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USP28 increases the amount of SOX9. 4 / 4
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"In contrast, the overexpression of USP28 increased both endogenous and exogenous protein levels of SOX9 in a dose-dependent manner (Fig. 3B and Fig. S3B, C)."
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"However, the catalytically inactive form (USP28 ) or the ΔUSP truncation mutant of USP28 (USP28 ) failed to enhance the expression of SOX9 (Fig. 3C)."
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"The pharmacological inhibitor of USP28, AZ1, decreased the protein levels of USP28 itself and that of SOX9 in a dose-dependent manner (Fig. 3J)."
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"Firstly, we investigated whether USP28 can modulate the expression level of SOX9."
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