IndraLab

Statements

Cycloheximide activates USP7. 4 / 4
| 4
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"Finally, we transiently overexpressed USP7 in HCT116 p53 -/- cells, treated with cycloheximide to block new protein synthesis and observed a significant increase in SUV39H1 half-life (XREF_FIG), confirming that USP7 positively regulates SUV39H1 protein stability."
26971997
reach
"The stabilizing effect of USP7 upon E1B-55K was further supported by cycloheximide chase assays demonstrating a reduced half-life of E1B-55K in the USP7 knockdown background (XREF_SUPPLEMENTARY) and after HBX or HBX41108 treatment (XREF_SUPPLEMENTARY)."
23555268
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"Moreover, control or USP7 knockdown cells were treated with cycloheximide (CHX), and endogenous MLL5 protein levels evaluated for the indicated times."
26678539
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"Cells were overexpressed for KDM6B and USP7 expression and were treated with 50mug/mL cycloheximide."
33434305