IndraLab

Statements


USP12 leads to the phosphorylation of AKT. 2 / 2
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"Knockdown of Usp12, or its complex members Uaf-1 and WDR20, increased Akt phosphorylation without any change to the total Akt protein in PC cells."

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"Secondly, Usp12 deubiquitinates and stabilises PHLPP and PHLPPL proteins which enhances dephosphorylation and deactivation of Akt."