IndraLab

Statements

Glutathione inhibits JUN. 10 / 11
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"Rokutan et al. [34] have reported that elevated levels of GSH inhibit the oxidant-induced activation of c-Jun and ATF-2."
21094128
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"In human hepatoma cells, GSH inhibited the egg product-induced activation of ERK, c-JUN, and STAT3 (Fig. 5A-C)."
36590323
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"We hypothesized that stretch induced cytokine production is dependent on oxidant release and is regulated by intracellular glutathione (GSH) inhibition of nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1) binding."
14982601
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"Glutathione depletion inhibits oxidant induced activation of nuclear factor-kappa B, AP-1, and c-Jun and ATF -2 in cultured guinea-pig gastric epithelial cells."
9773928
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"The nuclear c-Jun phosphorylation was not observed in cells treated with reduced glutathione."
15069077
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"We hypothesized that stretch induced cytokine production is dependent on oxidant release and is regulated by intracellular glutathione (GSH) inhibition of nuclear factor kappa B (NF-kappa B) and activator protein-1 (AP-1) binding."
14982601
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"Conversely, there is also evidence that increased cellular glutathione levels by NAC inhibit the expression and transcriptional activity of c-Jun triggered by numerous stimuli XREF_BIBR, including the binding of c-Jun to the AP-1 element within the VEGF promoter XREF_BIBR."
24291398
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"GSH supplementation blocked JNK/c-Jun activation and cell death, demonstrating that JNK/c-Jun overactivation is the downstream effect of GSH depletion."
36232313
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"Besides, GSH depletion induced inflammation stress in neuronal tissues of PD patients by modulating IL-1 signaling and JNK- (c-Jun N-terminal kinase-) activated inflammatory pathways [105, 106]."
34567415
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"An increase in mitochondrial GSH levels in HepG2 cells protects cytochrome C and inhibits necroptosis via the c-Jun N-terminal kinases pathway [104]."
39966277