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CK2 phosphorylates USP13. 5 / 5
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"We then addressed whether CK2 phosphorylates USP13 in the cellular context by inhibiting CK2 kinase activity in cells with CK2 inhibitors, silmitasertib (CX-4945) and 4,5,6,7-tetrabromobenzotriazole (TBB) [33,34,35]."
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"Western blotting with an anti-pT122 antibody showed that CK2 phosphorylated GST-USP13 protein but not GST, indicating that USP13 is a substrate of CK2 in vitro ( xref D), suggesting that USP13 is a substrate for CK2."
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"Further studies will determine whether CK2-mediated Thr122 phosphorylation affects the deubiquitinase activity of USP13, USP13-interactome network, or other PTMs on USP13."
36612196
sparser
"We then addressed whether CK2 phosphorylates USP13 in the cellular context by inhibiting CK2 kinase activity in cells with CK2 inhibitors, silmitasertib (CX-4945) and 4,5,6,7-tetrabromobenzotriazole (TBB) [ xref , xref , xref ]."
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sparser
"Previous studies have identified various regulatory mechanisms of USP13, including METTL3 and IGF2BP2-dependent N6-methyladenosine modifications of USP13 [ xref ] and CK2-induced phosphorylation of USP13 [ xref ]."
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