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CACNA1A inhibits PLK1. 1 / 1

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"BI 2536 and BI 6727 potently inhibit PLK1 as well as PLK2 and PLK3, and the inhibitor‐induced G 2 /M arrest was followed by strong induction of apoptosis. xref In contrast, GSK461364 has selectivity for PLK1 compared with PLK2 and PLK3, and the high concentration of GSK461364 induces G 2 delay rather than mitotic arrest. xref Thus, pharmacological phenotypes of GSK461364 seem to be different from those of BI 2536 and BI 6727, especially regarding apoptosis‐inducing effects at higher concentrations."

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CACNA1A inhibits PLK1. 1 / 1

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