IndraLab

Statements

USP11 decreases the amount of KLF4. 5 / 5
| 1 4
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"USP11 degrades KLF4 via its deubiquitinase activity in liver diseases."
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"Deletion of USP11 led to up‐regulation of KLF4 expression (Figure 4A) and longer KLF4 half‐life (Figure 4B)."
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"The USP11 negatively regulating KLF4 expression in HCC patients was on average augmented by 4.3‐fold (USP11: 207 and KLF4: 48)."
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"USP11 inhibits KLF4 expression by cleaving K63-linked polyubiquitin chains in HepG2 hepatocarcinoma cells [34]."
| PMC
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"These findings suggest that USP11 negatively regulates KLF4 expression in HCC patients.In summary, this is the first study describing USP11 as a modulator of KLF4 in liver dysfunction."
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