IndraLab

Statements

Calcium(2+) inhibits KCNK2. 3 / 3
| 3
reach
"The inhibition of TREK by Ca 2+ is somewhat curious, because TREK in general is not thought of as a Ca 2+ -sensitive channel."
25476848
reach
"Among Ca 2+ -associated K2P channels, TRESK is unique because TRESK channels are activated by elevations in the cytoplasmic Ca 2+ concentration via dephosphorylation by calcineurin, whereas other Ca 2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34289346
reach
"Since Ca store-active drugs were reported to block TREK-1 channels (18,19), it is intriguing to investigate whether bepridil can regulate the TREK-1 activity at a clinically therapeutic concentration.Furthermore, BL1249 has previously been validated to be specifically active in the TREK-1 channel, not only in heterologous expression systems but also in primary cells (20,21), which act on a gating mechanism involving a site located below the selectivity filter and the C-type gate (2)."
34430564