IndraLab

Statements

USP22 increases the amount of IL2. 8 / 10
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"Depletion of USP22 in T cells inhibits IL2 transcription by regulating NFATc2 stability."
31078284
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"USP22 can deubiquitinate and stabilize NFATC2 to activate T cells and upregulate IL-2 release."
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"Knockdown of USP22 decreases IL2 expression in Jurkat cells upon activation."
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"Taken together, these data suggest that USP22 positively regulates TCR-induced T cell activation by restricting IL2 production.To investigate how USP22 upregulates IL2 expression, we hypothesized that[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, we showed that USP22 stabilizes NFATc2 protein and promotes NFATc2 function to facilitate IL2 expression in T cells.Previous studies reported that USP22 regulates gene transcription in a [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP22 can promote the expression of interleukin-2 in T cells by deubiquitinating and stabilizing NFATc2 (an important regulator of T-cell activation)—a novel role for USP22 as a positive regulator of NFATc2 in the control of T-cell immune responses (25)."
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"Interestingly, USP22 has recently been identified to positively regulate NFATc2 and promote IL-2 expression, which might function redundantly with USP15 in regulating Th cell differentiation [113] ."
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"NFATc2 is a regulatory molecule in T-cell activation, and USP22 promotes interleukin-2 expression in T cells by deubiquitinating and maintaining the stability of NFATc2."
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