IndraLab

Statements

USP7 activates Carcinogenesis. 7 / 7
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"Another study further revealed that LINC00265 was able to regulate ZMIZ2 and USP7-mediated stabilization of β-Catenin, thereby facilitating colorectal tumorigenesis [39]."
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"Also , USP7 regulates PTEN localization and eventually inducing tumorigenesis ."
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"Therefore, USP7 is able to promote breast carcinogenesis through the USP7/PHF8/cyclin A2 axis (Wang et al., 2016b; Xia et al., 2019)."
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"USP7 also promotes carcinogenesis through aberrant activation of the Wnt signalling pathway and stabilization of HIF-1α."
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"USP7 ( HAUSP ) , which is known to regulate p53 availability in the cell through its direct stabilization and / or indirectly by stabilizing MDM2 [ 118 ] , was shown to have the ability to deubiquitylate HIF-1alpha under normoxia and to promote epithelial-mesenchymal transition and carcinogenesis [ 119 ] ."
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"USP7 also promotes carcinogenesis through aberrant activation of the Wnt signalling pathway and stabilization of HIF-1alpha."
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"USP7 also promotes carcinogenesis through aberrant activation of the Wnt signalling pathway and stabilization of HIF-1alpha ."
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