IndraLab

Statements

Leu-Thr inhibits CASP1. 5 / 5
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"Proteasome inhibitors block LT mediated caspase-1 activation and can protect against cell death, indicating that the degradation of at least one cellular protein is required for LT mediated cell death."
18266992
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"Loss of NALP1b or caspase-1 provided protection against LT induced cell death in LT sensitive macrophages, suggesting that LT induces caspase-1 dependent cell death."
19154716
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"The heat shock inhibition of LT mediated caspase-1 activation was not specific to the Nalp1b (NLRP1b) inflammasome, as heat shock also inhibited Nalp3 (NLRP3) inflammasome mediated caspase-1 activation in macrophages."
18671821
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"In this study, we found that heat shock can rapidly prevent anthrax LT induced macrophage death by inhibiting caspase-1 activation, an event known to be required for cell death from LT."
18671821
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"However, the heat shock inhibition of LT mediated caspase-1 activation was not specific to the Nalp1b (NLRP1b) inflammasome, as heat shock also inhibited Nalp3 (NLRP3) inflammasome mediated caspase-1 activation in macrophages."
18671821