IndraLab

Statements

OTUB1 inhibits ubiquitination. 7 / 9
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"In addition to USP 3 and 44, the ovarian tumor deubiquitinase ubiquitin aldehyde binding 1 (OTUB1) interferes with the interaction between RNF168 and UBC13 and inhibits H2A ubiquitination ( xref )."
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"While the authors determined S16 phosphorylation does not affect the DUB or non-canonical activities of OTUB1, they did demonstrate that cytoplasmic localization was required for OTUB1 to inhibit chromatin ubiquitination in response to DNA damage."
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"Consistent with the observation that OTUB1 inhibits RAS ubiquitination, analysis of RAS localization revealed that OTUB1 overexpression augmented the presence of RAS proteins on the plasma membrane (Fig  xref E and F; xref )."
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"In this study, we show that Otub1 inhibits MDM2-mediated MDMX ubiquitination, leading to the stabilization of MDMX, its accumulation in mitochondria and the cytosol, p53 S46 phosphorylation, and mitochondria-mediated apoptosis."
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"Further studies revealed that endogenous OTUB1 can inhibit the ubiquitination of phosphorylated Smad2/3 and prevent its proteasomal degradation ( Fig. 4 )."
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"Investigation into the biological mechanism revealed that OTUB1 inhibits NEDD4L-mediated ubiquitination of SMAD2 and SMAD3 in a manner dependent on lysine residue K17 and the N-terminus of OTUB1."
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"A study from 2012 found that OTUB1 non-canonically inhibits MDM2-mediated ubiquitination of P53 to promote its stabilization ( xref )."
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