IndraLab

Statements

USP3 activates DDR. 4 / 4
| 4
reach
"Isolation of USP3 interacting partners and potential additional substrates, as well as addressing if and how USP3 is regulated, is needed to gain a better understanding of the molecular mechanism of USP3 mediated DDR."
18430235
reach
"Overall, despite the non-specificity towards H2A ubiquitination [74], current data support the notion that USP3, at least in part, counteracts the RNF168-mediated pathway in regulating the DDR."
33797206
reach
"Knockdown of USP3 impairs the DDR through SMARCA5 and results in increased sensitivity to Docetaxel treatment in prostate cancer cells."
39500888
reach
"38 Conversely, Das et al. report that the upregulation of USP3 stimulates the DDR, evident from a substantial increase in γ‐H2AX following USP3 overexpression."
38651282