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USP10 inhibits NFkappaB. 4 / 7
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"Suppression of genotoxic NF-kappaB activation by MCPIP1 and USP10."
28626800
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"Previous studies have reported that USP10 could inhibit the activation of NF-kB and the release of inflammatory cytokines, while USP10 silencing can markedly increase NF-kB activation.27,28 In mice with tMCAO, the relationship between USP10 and VNS stimulation was reported by Xie et al.29 They found that USP10 expression in the brain was decreased after ischemic stroke, and VNS treatment could counteract it by increasing the expression of USP10 and ameliorating neurological deficits."
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"For example, USP10 can inhibit genotoxic NF-kappaB activation through monocyte chemotactic protein-1-induced protein-1 (MCPIP1)-facilitated deubiquitination of NEMO [XREF_BIBR]."
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"A previous study demonstrated that USP10 inhibits NF-kappaB activation and inflammatory cytokine induction ( 22 ) ."
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