IndraLab

Statements


UCHL5 increases the amount of CTNNB1. 4 / 4
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"Meanwhile, deletion of UCH37 decreased the levels of beta-catenin and the early endosomal protein Rab8."

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"In contrast, UCHL5 overexpression in AN3-CA cells elevated the expression of β-catenin and its effector proteins (CyclinD1, C-myc, Survivin) and decreased cleaved-caspase3 (Figures 5D–F)."

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"As shown in Figure 5A, UCHL5 knockdown decreased the expression of β-catenin."

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"In the study, UCHL5 overexpression elevated the levels of β-catenin and regulated its downstream genes (CyclinD1, C-myc, Survivin, and cleaved-caspase3), which were counteracted by the Wnt/β-catenin inhibitor XAV939."