IndraLab

Statements

CYLD activates E3_Ub_ligase. 3 / 3
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"Thus, it is possible that CYLD functions in diverse pathways and loss of CYLD activity contributes to tumorigenesis via multiple mechanisms.Lys63-linked ubiquitin chains, synthesized in response to cy[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Additionally, CYLD interacted with FZR1 to promote APC/C-FZR1 E3 ligase activity, which further ubiquitinated and degraded PFKFB3 via the 26S proteasomal system."
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"Lim and co-workers showed that CYLD suppresses TGF-beta signalling and prevents lung fibrosis by (indirectly) reducing the stability of Smad3, in an AKT, GSK3beta and E3 ligase carboxy terminus of Hsc[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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