IndraLab

Statements

OTUB2 binds smo-1. 4 / 4
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"Sumoylated OTUB2 interacts specifically with yet-unidentified sumo interaction motifs (SIMs) in WW domain-containing transcription factor (TAZ) and Yes-associated protein (YAP) to regulate protein activity and TAZ/YAP polyubiquitination in a Hippo-independent manner."
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"No OTUB2-SUMO PLA signal was detected for the SUMOylation-deficient mutant K233R ( Figure 4 F), validating the specificity of the SUMO-PLA assay."
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"Moreover, although purified YAP/TAZ could not directly interact with OTUB2-WT in vitro , it did bind OTUB2-SUMO chimera that might mimic SUMOylation (OTUB2-SUMO3; Figure 5 B)."
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"Deubiquitination of YAP/TAZ by OTUB2 depends on the presence of a poly-SUMO chain conjugated to OTUB2 lysine 233, as SUMOylation enables OTUB2 interaction with a novel SUMO-interacting motif (SIM) ide[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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