IndraLab

Statements

USP7 activates Cell Survival. 14 / 15
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"USP7 promoted myeloma cell survival, and when it was inhibited by its specific inhibitor P5091, myeloma cell lines underwent apoptosis."
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"The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival."
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"USP7 promotes MM cell survival by deubiquitinating Maf proteins , including c-Maf , MafA , and MafB , which are critical transcription factors in myelomagenesis ."
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"USP7 inhibition decreases cell viability."
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"These findings demonstrated that USP7 can positively regulate the OC cell viability."
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"Our results demonstrated that an increase in serine concentration could cause USP7 to activate YAP by removing the poly-ubiquitin chain , therefore promoting cell survival and proliferation ( Figure 6C ) ."
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"XREF_FIG, USP7 inhibition with P22077 significantly reduced cell viability in three different primary AML samples, while PBMCs were barely affected by the treatment."
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"For example, USP2 and USP7 modulate p53 and MDM2, impacting cell survival and tumor development, while USP22 stabilizes c-Myc, driving cancer proliferation and metastasis [9–13]."
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"XREF_BIBR - XREF_BIBR Targeted by various viral proteins, USP7 can promote cell survival and viral infection, living up to its original name of herpesvirus associated USP."
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"The results showed that upregulation of USP7 significantly increased the cell viability of ESCs compared with the control group ( Fig. 2 A)."
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"First, we demonstrated that the inhibition of USP7 significantly reduced cell viability, cell proliferation, and cell-cell adhesion in 2D and 3D cultures."
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"USP7 knockdown significantly restored the impaired cell viability by LPS stimulation, while this rescuing effect was prevented by YAP silencing (Figure 7E)."
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"In a subset of TP53-mutant cell lines, such as the pancreatic cancer Capan-1 cells harboring the TP53 p.A159V mutation, USP7 inhibition has been shown to decrease cell viability ."
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"Then the cell viability was assessed by MTT assay and as shown in Fig. 2 C, inhibition of USP7 significantly impaired the cell viability compared to non-treated or sh-NC transfected group in C33A and [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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