IndraLab

Statements

USP7 activates Cell Survival. 11 / 12
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"XREF_FIG, USP7 inhibition with P22077 significantly reduced cell viability in three different primary AML samples, while PBMCs were barely affected by the treatment."
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"These findings demonstrated that USP7 can positively regulate the OC cell viability."
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"The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival."
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"Usp7 promotes medulloblastoma cell survival and metastasis by activating Shh pathway."
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"USP7 promoted myeloma cell survival, and when it was inhibited by its specific inhibitor P5091, myeloma cell lines underwent apoptosis."
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"USP7 inhibition decreases cell viability."
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"By overexpressing PLK1, USP7 that had been depleted by RNAi ceased to induce chromosome misalignment in mitosis and again supported cell proliferation and cell survival."
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"USP7 promotes MM cell survival by deubiquitinating Maf proteins , including c-Maf , MafA , and MafB , which are critical transcription factors in myelomagenesis ."
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"Our results demonstrated that an increase in serine concentration could cause USP7 to activate YAP by removing the poly-ubiquitin chain , therefore promoting cell survival and proliferation ( Figure 6C ) ."
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"XREF_BIBR - XREF_BIBR Targeted by various viral proteins, USP7 can promote cell survival and viral infection, living up to its original name of herpesvirus associated USP."
27051296
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"As shown in Fig. 2a, USP7 inhibition with P22077 significantly reduced cell viability in three different primary AML samples, while PBMCs were barely affected by the treatment."
32447346