IndraLab

Statements

UCHL1 inhibits ESR1. 4 / 4
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"These results indicate that ERalpha restoration by UCH-L1 repression is functionally active ."
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"In addition, UCHL1 knockdown increased the transcriptional activity of estrogen receptor (ER) in the estrogen-treated breast cancer cell lines [46]."
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"Up-regulation of ERalpha caused by UCH-L1 inhibition could significantly enhance the efficacy of tamoxifen and fulvestrant in ERalpha (-) breast cancer both in vivo and in vitro."
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"UCHL1 can increase resistance to endocrine therapy by increasing the degradation of estrogen receptor α (ERα) via EGFR [11]."
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