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USP12 activates Neoplasms. 4 / 4
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"Furthermore, depletion of USP12 effectively inhibited gastric cancer tumor growth in vivo in a xenograft model, and overexpression of YAP rescued this effect (Fig. 5K–M)."
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"The absence of USP12 reduces the infiltration of mononuclear (M)-MDSCs and impairs their suppressive function, leading to enhanced CD8 + T-cell responses and reduced tumor growth [60]."
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"For example, AKT-mTOR signaling in KRAS G12D NSCLC generates a tumor-promoting secretome and tumor-associated macrophage (TAM)-infiltration by downregulating the deubiquitinase, USP12 [ 20 ]."
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"Similar tumor-inducing effects of USP12 were observed in C33A cells and PC cells ( Burska et al., 2013, Lehoux et al., 2014 and McClurg et al., 2014 )."
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