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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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Statements

Proteasome inhibits USP1. 3 / 3

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"Upon UV DNA damage, USP1 is auto-cleaved and degraded by the proteasome."

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"First, transcription of the USP1 gene is turned off, and second, the USP1 protein present in the cells is quickly degraded by the proteasome, in a process that appears to be initiated by an endo-proteolytic cleavage (possibly autocleavage) at an internal GG motif of USP1."

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"USP1 gets cleaved, and subsequently degraded by the proteasome system in response to UV light exposure, but not to alkylating or cross linking agents [XREF_BIBR, XREF_BIBR]."

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Statements

Proteasome inhibits USP1. 3 / 3

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