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Rolapitant inhibits OTUD3. 8 / 8
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"But we found that when Rolapitant was added to lung cancer cells, Rolapitant inhibits the deubiquitinating activity of OTUD3, thereby promoting GRP78 ubiquitination and resulting in its degradation."
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"Based on our data, we propose that Rolapitant directly inhibit the deubiquitinating activity of OTUD3 through binding to OTUD3 to cause the downregulation of GRP78 protein levels."
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"The results indicated that Rolapitant inhibited the deubiquitinating activity of OTUD3 to cleave K48- linked di-Ub (Fig. 3E)."
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"Rolapitant inhibits lung cancer cell growth by targeting OTUD3."
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"These results implied that Rolapitant suppresses the proliferation of lung cancer cells via OTUD3."
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"Rolapitant inhibits the deubiquitinating activity of OTUD3."
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"Next, we performed in vitro deubiquitination assays to further verify whether Rolapitant inhibits the deubiquitinating activity of OTUD3 in vitro."
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"Rolapitant inhibited the proliferation of lung cancer cells by inhibiting deubiquitinating activity of OTUD3."
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