IndraLab

Statements

USP18 decreases the amount of POU4F1. 3 / 3
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"Furthermore, we found that USP18 knockdown elevated the protein ubiquitination level of POU4F1 and reduced POU4F1 protein level, which implicated that USP18 promoted POU4F1 protein expression via inducing de-ubiquitination."
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"Moreover, enzyme-dead USP18-C64S mutant resulted in the prominent inhibition of POU4F1 protein level and it reversed USP18-induced reduction of ubiquitination level of POU4F1 (Supplementary Fig. 1C)."
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"In addition, knockdown of USP18 reduced the protein expression of POU4F1 but increased the ubiquitination level of POU4F1 (Fig. 3D)."
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