IndraLab

Statements

KCNG1 activates RNA binding. 4 / 4
| 4
reach
"Supporting this hypothesis, a missense mutation (I304N), known to alter the KH2 mediated RNA binding properties of FMRP, abolishes the localization of human FMRP ISO6 to Cajal bodies."
24204304
reach
"The I304N mutation causes defective KH2 mediated RNA binding in neurons, and decreased FMRP levels, particularly in younger animals."
20011099
reach
"Chemical shift perturbation data confirm that RNA binding is mediated by the canonical RNA binding grooves of KH2 and KH3."
20385598
reach
"These data suggest that loss of FMRP function, particularly in KH2 mediated RNA binding and in synaptic plasticity, play critical roles in pathogenesis of the Fragile X Syndrome and establish a new model for studying the disorder."
20011099