IndraLab

Statements

NAC inhibits CHUK. 4 / 4
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"Regarding the mechanism underlying NAC mediated suppression of IKKalpha and IKKbeta, a possible explanation is that NAC directly inhibits the kinase activity of IKKalpha and IKKbeta."
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"The induction of reporter genes by TRADD, TRAF2, NIK, IKKalpha, or IKKbeta decreased partially when the cells were treated with NAC for 6 h in a dose dependent manner."
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"Furthermore, NAC suppressed the activation of IKKalpha and IKKbeta triggered by the overexpression of NIK."
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"In this respect, however, it should be noted that NAC failed to inhibit IKKalpha and IKKbeta activity in vitro (data not shown), indicating that NAC mediates the suppression of these kinases through a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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