IndraLab

Statements

USP25 activates cell death. 3 / 3
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"In this report, we found that PdPT is an inhibitor of multiple DUBs including USP7, USP10, USP14, USP15, USP25 and UCHL5, which contributes to the accumulation of ubiquitinated proteins and subsequent cell death in NSCLC cell lines.Regulated cell death requires activation of various regulators and effectors (23)."
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"Therefore, USP21 stimulates cell proliferation but can not cause cell death."
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"PDAC is characterized by a severely hypoxic microenvironment, and USP25 depletion abrogates HIF-1alpha transcriptional activity and impairs glycolysis, inducing PDAC cell death in the tumor hypoxic core."
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