IndraLab

Statements

Hydroxychloroquine decreases the amount of IFNB1. 3 / 3
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"Importantly, treatment with X6, but not HCQ, significantly reduces IFN-β and ISG expression in Trex1 mice and PBMCs from SLE patients."
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"Addition of HCQ suppressed the expression of IFN-α, IFN-β, TNF-α, and IL-6 in both G/G and A/A pDCs (Supplemental Figure 10, A and B)."
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"Hydroxychloroquine, an anti-malarial agent that is known to inhibit activation of endosomal Toll like receptors 7 and 9 by exogenous nucleic acid ligands 43, has been recently shown to inhibit cGAS and thus block downstream IFN-beta expression."
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