IndraLab

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USP25 activates cell population proliferation. 74 / 74
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"USP21 overexpression significantly promoted cell proliferation (Fig. 2c), whereas USP21 silencing inhibited cell proliferation (Fig. 2d)."
31956270
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"Inhibition of USP21 in HCC cell lines decreased cell proliferation, anchorage independent growth, cell cycle progression, and in vivo tumor growth."
29706623
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"Nguyen et al. reported that USP21 knocking down USP21 increases the activity of YAP/TAZ and cell proliferation in A549 cells [24]."
37743467
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"Both CCK-8 and EdU immunofluorescent staining assays indicated that compared with the control group, suppression of USP21 notably inhibited nasopharyngeal carcinoma cell proliferation (Figures 1(f) and 1(g))."
36820242
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"Ectopic USP21 expression promotes hepatocyte cell proliferation and tumor growth."
29706623
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"However, another study reported that USP21 promotes non-small cell lung cancer (NSCLC) cell proliferation, migration, and invasion, including A549 cells, by deubiquitinating and stabilizing an oncoprotein, Yin Yang-1 (YY1) [43]."
37743467
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"XREF_FIG, ectopic USP21 expression markedly increased cell proliferation and anchorage independent growth."
29706623
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"USP21 upregulation in cholangiocarcinoma promotes cell proliferation and migration in a deubiquitinase dependent manner."
33052017
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"USP21 silencing inhibited proliferation, migration and invasion and induced apoptosis of HCC cells, accompanied by the increased E-cadherin protein expression and decreased N-cadherin and Vimentin protein expression."
39680331
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"Interestingly, it was observed that USP21 knockdown also inhibited HCC proliferation (Fig. 9E and 9F)."
37875823
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"These results demonstrate that USP21 promotes cell proliferation by inducing cell cycle progression in HL-7702 and MHCC97L cell lines."
29706623
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"Knockdown of NRF1 or USP21 inhibited HCC cell proliferation, whereas it had no impact on normal human liver cell (HL-7702) proliferation."
37875823
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"Plate clone formation assays showed that low expression of USP21 significantly inhibited the proliferation of CCA cells, while overexpression of USP21 enhanced the proliferation of CCA cells (Figure 2A-B)."
38385089
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"USP21 inhibition decreases HCC cell proliferation and tumor growth."
29706623
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"Knockdown of USP21 inhibited the proliferation of BC cells, whereas overexpression of circCD2AP reversed this change (Figure S1D)."
38292422
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"By maintaining EZH2 protein levels, USP21 promotes cell proliferation and metastasis in bladder carcinoma and cell proliferation in diffuse large B-cell lymphoma (Chen et al., 2017b; Ma et al., 2021)."
35846989
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"In bladder cancer cells, increased expression of USP21 promoted cell proliferation, stimulated cell migration and invasion, enhanced tumor metastasis (45)."
37215134
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"These results show that the overexpression of USP21 is sufficient to increase HCC cell proliferation in vitro and promote tumor growth in vivo."
29706623
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"USP21 promoted the proliferation of CCA in vitro and in vivo."
38385089
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"In this study, we found USP25 knockdown distinctly suppressed the proliferation and migration of DLBCL cells."
37480689
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"Additionally, the deletion of USP25 induced the degradation of BCR-ABL and inhibited its downstream STAT5-related signal transduction, as well as the proliferation of Ph-positive leukemic cells."
38947742
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"Moreover, rescue experiment also confirmed that USP25 promoted the proliferation and migration of DLBCL cells via stabilizing MDM2 protein via deubiquitination."
37480689
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"These results suggested that USP21 can promote CCA cell proliferation in vitro."
38385089
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"Subsequently, we observed that knockdown of circCD2AP or USP21 could repress BC cell proliferation, whereas FOXQ1 overexpression blocked this effect (Figure 6C)."
38292422
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"Cell counting and 5-ethynyl-2 '-deoxyuridine incorporation assays reveal that USP21 promotes the proliferation of cholangiocarcinoma."
33052017
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"In conclusion, we demonstrated that USP21 promoted CCA proliferation in vivo."
38385089
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"In addition, rescue assays reveal that reintroduction of USP21 wildtype other than the deubiquitinase deficient C221A mutant restores USP21 depletion induced attenuation in cell proliferation and migration, indicative of the requirement of the deubiquitinase activity."
33052017
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"USP21 promoted the proliferation of CCA cells by enhancing aerobic glycolysis through the HIF-1 signaling pathway."
38385089
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"For example, a majority of studies indicated that USP21 supported proliferation and progression, as well as potential immunosuppression in distinct cancer types, whereas the suppressive roles of USP21 have also been reported."
35846989
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"USP21 knockdown dramatically decreased cell proliferation rate examined by CCK8 assay."
33389794
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"XREF_BIBR, XREF_BIBR Recently, one report indicated that USP21 promotes cell proliferation and invasion ability in human renal cell carcinoma."
28223825
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"Therefore, USP21 stimulates cell proliferation but can not cause cell death."
33389794
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"We found that overexpression of USP21 dramatically increased cell proliferation, while USP21-CA could not."
33389794
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"Subsequently, according to a series of experiments, we observed that overexpression of USP25 promoted HCC cell proliferation, migration, and invasion both in vitro and in vivo; in particular, HCC cells noticeably spread to the lungs."
37439386
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"These data demonstrate that USP21 promotes cell proliferation via its deubiquitinating active site."
33389794
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"In addition, several functional experiments indicated that USP21 not only promoted cell proliferation but also facilitated metastasis through regulation epithelial-mesenchymal transition (EMT) process."
28223825
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"Overexpression of USP21 promotes proliferation of BC cells."
28223825
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"As shown in XREF_FIG, ectopic expression of USP21 obviously increased the proliferation rates of 5637 and T24 cells, whereas the inhibition of USP21 expression significantly inhibited cell proliferation."
28223825
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"Thus, we hypothesized that USP21-mediated enhancement of glycolysis plays a role in the proliferation of CCA cells."
38385089
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"USP21 promotes cell proliferation and metastasis through suppressing EZH2 ubiquitination in bladder carcinoma."
28223825
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"The expression of USP21 promoted DLBCL cell proliferation, while it had no obvious effect on cell death."
33389794
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"Upon preparing this manuscript, one recent study reported that USP21 promotes proliferation and glycolysis of esophageal cancer cells [30], however, whether the oncogenic role of USP21 depends on its deubiquitinase activity or not remains unknown."
38906857
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"USP21 can promote tumorigenesis by increasing the cell proliferation, migration, and invasion of non-small cell carcinoma cells ."
37714937
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"Together, our findings demonstrated that USP21 promoted cell proliferation in BC."
28223825
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"Collectively, these results demonstrated that USP25 promotes HCC cell proliferation, migration, and invasion."
37439386
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"Furthermore, USP21 modulates the STAT3/FOXO1 pathway to accelerate cell proliferation and glycolysis in esophageal cancer[11]."
38577450
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"We reported that USP21 promoted GC cell proliferation, migration, invasion, and stemness in vitro, and regulated GC tumor growth and cell stemness in mice in vivo."
33791299
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"We identify that knockdown of USP21 inhibits cell proliferation, and overexpression of USP21 promotes cell growth."
33389794
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"These data revealed that USP21 not only promoted cell proliferation but also facilitated cell migration and invasion in BC."
28223825
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"These results hinted that USP21 was significantly expressed in nasopharyngeal carcinoma tissues and cell lines, and knockdown of USP21 inhibited proliferation of nasopharyngeal carcinoma cells."
36820242
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"CCK-8 and EdU immunofluorescent staining assays revealed that USP21 promoted the proliferation of nasopharyngeal carcinoma cells."
36820242
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"Our study clarified the upstream regulatory mechanisms underlying abnormal activation of Wnt/β-Catenin signaling which provides new insight for the therapeutic strategy against this pathway.Furthermore, we introduced DSF, against USP21 deubiquitylation activity, and explored its effect on USP21-mediated proliferation and metastasis in ESCC."
38906857
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"USP21 Promotes the Proliferation, Migration, Invasion, and Stemness of GC Cells."
33791299
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"Additionally, USP21 contributes to cell proliferation and migration in cholangiocarcinoma[12]."
38577450
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"These results demonstrated that USP21 stimulated cell proliferation, migration, invasion, and stemness of GC cells."
33791299
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"These results strongly supported the crucial role of G3BP1 in USP21-mediated ESCC proliferation and metastasis."
38906857
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"Since USP21 stimulated cell proliferation, migration, invasion, and stemness of GC, and could stabilize the expression of GATA3 by deubiquitinating GATA3, while MAPK1 was the transcription target of GATA3, it was further verified whether USP21 could play its oncogenic effect in GC through the GATA3 and MAPK1 axis."
33791299
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"USP21 promotes cell proliferation in vitro."
31956270
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"The expression of USP21 may promote proliferation, migration and invasion of breast cancer cells."
28105162
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"In non small cell lung cancer, USP21 promotes tumor cell proliferation, migration, and invasion through the YY1 and SNHG16 axis."
33791299
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"In bladder cancer, USP21 is highly expressed and patients with high expression levels have poor survival, and USP21 can accelerate the proliferation and metastasis of bladder cancer cells via inhibiting EZH2 ubiquitination."
33791299
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"Conversely, OE of USP21 promoted the cell proliferation of ovarian cancers and conferred resistance to BAY 11-7082."
37964466
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"USP25 promotes HCC cell proliferation, migration, and invasion in vitro ."
37439386
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"Thence, in vitro cell experiments were performed and it was found that overexpression of USP21 promoted cell proliferation, migration, invasion, EMT, and stemness, whereas inhibiting its expression posed opposite effects."
33791299
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"Moreover, USP21 overexpression promoted cell proliferation (Fig. 2B; Supplemental Fig. S2B) and anchorage-independent colony formation (Fig. 2C,D) of hTERT-HPNE E6/E7 and hTERT-HPNE E6/E7-KRAS cells."
31488580
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"The results from these assays indicated that USP25 promotes HCC cell proliferation, migration, and invasion by interacting with TRIM21, thereby regulating the Wnt/β-catenin signaling pathway and EMT [Figure 8]."
37439386
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"USP21 promotes cell proliferation and migration of CRC cells."
38834869
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"In non-small cell lung cancer, USP21 promotes tumor cell proliferation, invasion and migration through the YY1/small nucleolar RNA host gene 16 pathway (97)."
40230426
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"We also showed that USP21 contributed to the progression of tumorigenesis by increasing proliferation, migration, and invasion."
31956270
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"A study by Chen et al. reported that USP21 promoted cell proliferation and metastasis in bladder cancer via deubiquitinating EZH2 and stabilizing it."
31956270
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"Collectively, these results suggested that USP21 may promote the proliferation of CCA cells by enhancing aerobic glycolysis through the HIF-1 signaling pathway."
38385089
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"Moreover, the CCK-8 assay indicated that USP25 depletion dramatically decreased the proliferation of HepG2 and MHCC97H cells [Figure 2F]."
37439386
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"Here, in vitro and in vivo experiments revealed that aberrant upregulation of USP21 accelerated the proliferation and metastasis of ESCC in a deubiquitinase-dependent manner."
38906857
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"USP21 inhibition suppressed AMC-HN-8 and TU686 cell proliferation, migration and invasion."
36919585