IndraLab

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Sodium(1+) activates SCN1A. 2 / 2
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"This condition is genetically heterogeneous, with mutations in the KCNT1 gene that codes for a sodium activated potassium channel and mutations in SCN1A both described."
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"By contrast, lamotrigine, a widely used sodium channel blocking antiepileptic drug, caused Scn1a +/- mice to exhibit a higher seizure frequency consistent with observations made in human Dravet syndrome 12."
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