IndraLab

Statements

Modified miR-130b/301b decreases the amount of USP13. 4 / 4
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"Overexpression of miR-130b/301b or USP13 knockdown by shRNA delivery decreases USP13 expression, and further reduces PTEN protein expression and leads to enhancement of cell proliferation, invasion and migration."
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"We reported a potential regulatory loop that the NF-kB-induced miR-130b/301b overexpression decreased USP13 expression and subsequently resulted in the downregulation of PTEN protein and promoted tumorigenesis of bladder cancer."
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"Results showed that overexpression of miR-130b/301b dramatically decreased protein expression of USP13 and PTEN, while restoration of USP13 completely reversed the effect."
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"Results showed that overexpression of miR-130b/301b significantly decreased USP13 expression in transcription and translational levels, and knockdown of miR-130b/301b revealed an opposite effect on USP13 expression."
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