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KCND3 activates potassium(1+). 5 / 5
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"(2) Patients with diabetes are more prone to AF recurrence because the expression of Kv4.3, Kv1.5, and Cav1.2 in the diabetic myocardium are reduced, which leads to decreased calcium current and potassium current."
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"There were no major changes in expressions of KCND3, KCNQ1, KCNJ3, and KCNJ12 mRNA, which respectively encoded Kv4.3, Kv7.1, Kir3.1, and Kir2.2 separately and contributed to the cardiac transient outward potassium current (I ), slow delayed rectifying potassium current (I ), acetylcholine‐activated inward rectifier K current (I ), and inward rectifier current (I ) (Figure 6A)."
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"Kcnd3 encodes Kv4.3 and contributes to the cardiac transient outward potassium current (I to)."
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"Kv4.3 and Kv7.1 contribute to the fast transient outward potassium current (I ) and delayed rectifier potassium current (I ) in cardiomyocytes, respectively [30]."
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"Kv4.3 is activated and inactivated rapidly after membrane depolarization, promoting the sub-threshold A-type potassium current that controls the repolarization and frequency of action potential, thus preventing the excitability of neurons (Serôdio et al., 1996; Niwa and Nerbonne, 2010)."
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