IndraLab

Statements

4-aminopyridine inhibits KCNMA1. 5 / 5
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"Previously, TEA, 4-AP, and quinidine were reported to block mouse Slo-1 channels, where 250 μM TEA, 25 mM 4-AP, or 100 μM quinidine blocked the Slo1 current by 50% at 0 mV ( Tang et al., 2010 )."
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"For cytosolic block of Slo1 by 4-AP, a single-site, open channel block model gave a poor fit of the G/V curves (XREF_TABLE) with K b (0) = 24.2 +/- 1.3 mM with zdelta = 0.03 +/- 0.03 e."
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"Furthermore, the pH-dependence of block of Slo1 by 4-AP supported the idea that the protonated and nonprotonated forms of 4-AP produce block in distinct ways."
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"5-HT in the presence of 4-AP decreased the residual BK channel current significantly in FHH.1 BN rats but not in FHH rats (46 vs. 6%) (XREF_FIG, A and B)."
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"Extracellular 4-AP blocks Slo1 channels with minimal effects on Slo3, while cytosolic 4-AP is more effective on Slo3 than on Slo1."
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