IndraLab

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NEDD4 inhibits KCNQ1. 5 / 5
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"The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4 and Nedd4 like family."
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"The KCNQ1 potassium channel is down-regulated by ubiquitylating enzymes of the Nedd4 and Nedd4 like family."
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"Accordingly, NEDD4–2 co-expression dramatically reduced both KCNQ1 surface density (Fig. 4A,B) and whole-cell currents (Fig. 4C,D)."
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"Similar to NEDD4–2, ITCH significantly down-regulated both KCNQ1 channel surface density and ionic currents (Fig. 4A-D)."
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"Here we demonstrate that KCNQ1 proteins expressed in HEK293 cells are down-regulated by Nedd4 and Nedd4 like ubiquitin protein ligases."
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