IndraLab

Statements

Chlorpromazine inhibits KCNH2. 9 / 9
3 | 6
ctd
No evidence text available
12788816
reach
"(3) Chlorpromazine blocked HERG potassium channels with an IC (50) value of 21.6 micro M and a Hill coefficient of 1.11."
12788816
reach
"IC50 for chlorpromazine block of HERG current was progressively decreased according to depolarization : IC50 values at -30, 0, and +30 mV were 10.5, 8.8, and 4.9 microM, respectively."
15071359
ctd
No evidence text available
15071359
reach
"The antipsychotic drug chlorpromazine inhibits HERG potassium channels."
12788816
reach
"Thioridazine, perphenazine, trifluoperazine, and chlorpromazine blocked hERG potassium channels with the following IC (50) values : IC (50) values were 224 +/- 42 nM for thioridazine, 1003 +/- 71 nM for perphenazine, 1406 +/- 124 nM for trifluoperazine, and 1561 +/- 281 nM for chloropromazine."
16051556
reach
"Especially, it has been reported that thioridazine and chlorpromazine directly inhibited hERG channels, through which these drugs could induce long QT syndrome [XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR]."
28066143
reach
"The decrease became more pronounced at increasingly positive potential, suggesting that the blockade of HERG by chlorpromazine is voltage dependent."
15071359
ctd
No evidence text available
24052561