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Statements

Chlorpromazine inhibits KCNH2. 7 / 11
3 1 | 7
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"(3) Chlorpromazine blocked HERG potassium channels with an IC (50) value of 21.6 micro M and a Hill coefficient of 1.11."
12788816
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"The decrease became more pronounced at increasingly positive potential, suggesting that the blockade of HERG by chlorpromazine is voltage dependent."
15071359
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"IC50 for chlorpromazine block of HERG current was progressively decreased according to depolarization : IC50 values at -30, 0, and +30 mV were 10.5, 8.8, and 4.9 microM, respectively."
15071359
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"Especially, it has been reported that thioridazine and chlorpromazine directly inhibited hERG channels, through which these drugs could induce long QT syndrome [XREF_BIBR XREF_BIBR XREF_BIBR XREF_BIBR]."
28066143
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"Thioridazine, perphenazine, trifluoperazine, and chlorpromazine blocked hERG potassium channels with the following IC (50) values : IC (50) values were 224 +/- 42 nM for thioridazine, 1003 +/- 71 nM for perphenazine, 1406 +/- 124 nM for trifluoperazine, and 1561 +/- 281 nM for chloropromazine."
16051556
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"Thus, we concluded that human iPSC-CMs can recapitulate cardiotoxicity and identify the effects of well-characterized compounds.Previous studies have demonstrated that sotalol, chlorpromazine, and mexiletine inhibit hERG currents, which may explain the cardiac toxicity of these drugs [14-16]."
37078300
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"The antipsychotic drug chlorpromazine inhibits HERG potassium channels."
12788816