IndraLab

Statements

Potassium channel toxin alpha-KTx 16.2 inhibits KCNMA1. 3 / 3
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"Martentoxin, a 37 residues toxin from Buthus martensi Karsch (BmK), can block BK channel in adrenal medulla chromaffin cells and modulate the activities of neuronal BK channel subtype (alpha+ beta4) with Ca 2+ -dependent manner XREF_BIBR, XREF_BIBR."
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"Martentoxin blocks KCa1.1 formed of alphabeta4, whereas it opens KCa1.1 formed of alphabeta1 and has yet to be tested on KCa1.1 containing beta2 or beta3 subunits [XREF_BIBR]."
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"Martentoxin is a specific inhibitor of the BK channel, and thus understanding the interaction mechanism of martentoxin with the BK channel may provide valuable insights into the nature of BK channel inhibitors."
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