IndraLab

Statements

USP9X deubiquitinates NUDT1. 6 / 6
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"Co-IP data show that USP9X interacts with and deubiquitinates MTH1."
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"USP9X deubiquitinates MTH1 in HGC-27 cells."
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"We observed that overexpression of wildtype USP9X significantly reduced the ubiquitination of MTH1, while mutant USP9X had the opposite function (Fig. 3A)."
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"Conversely, knockdown of USP9X greatly upregulated MTH1 ubiquitination (Fig. 3B)."
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"Our observations that USP9X interacts with and deubiquitinates MTH1 in HGC-27 cells and controls the proliferation, survival, migration, and invasion of GC cells expand our knowledge about the function and target of USP9X in cancer biology."
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"In summary, our study reveals that USP9X can control the proliferation, survival, migration and invasion of GC cells by interacting with and deubiquitinating MTH1."
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