IndraLab

Statements

USP9X inhibits E3_Ub_ligase. 2 / 2

| 2

reach

"USP2215, USP2816 17, USP3718, and OTUD6A19 directly deubiquitinate c-Myc, increasing tumorigenesis, while USP9X indirectly reduces c-Myc by stabilizing its E3 ligase Fbw7, thereby inhibiting CRC growth20.HMGA2 is an architectural transcription factor composed of 109 amino acids and three AT-hooks, which are basic DNA-binding domains."

38572092

➶

reach

"USP9x inhibited the E3 ubiquitin protein ligase TIF1gamma from binding and monoubiquitinating SMAD4, hence maintaining SMAD4 nuclear retention."

28115363

INDRA sources:

Colored badges next to statement headings correspond to evidence counts from knowledge sources, as shown below. Badges to the left of the | separator correspond to curated knowledge base sources, and badges to the right of it correspond to machine reading systems.

IndraLab

Statements

USP9X inhibits E3_Ub_ligase. 2 / 2

INDRA sources:

Databases

Reading