IndraLab

Statements

PCID:76516568 inhibits MAPK8. 4 / 4
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"JNK-IN-8 potently inhibits JNK1, 2 and 3 enzymatic activity with IC 50 s of 4.7 nM, 18.7 nM and 1.0 nM respectively and inhibits a c-Jun, a direct phosphorylation substrate of JNK, with an EC 50 of 486 nM in Hela cell."
23438744
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"We determined that inhibition of JNK1 and JNK2 by JNK-IN-8 was approximately equivalent in regards to decreased phosphorylation of c-Jun at the JNK specific, serine 63 site."
29285221
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"The result that JNK1 inhibition by JNK-IN-8 is important for synergy with lapatinib is not surprising considering that JNK-IN-8 was shown to have greater activity toward purified, recombinant JNK1 in vitro [ xref ]."
29285221
sparser
"This indicates that the inhibition of endogenous JNK1 by JNK-IN-8 is not greater than inhibition of JNK2."
29285221