IndraLab

Statements

PSMD14 inhibits cellular senescence. 6 / 6
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"Further, knockdown of PSMD14 significantly inhibited cell growth and caused G1 arrest and cellular senescence by increasing p21 stability in LUAD cells."
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"PSMD14 knockdown induces cell cycle arrest, senescence and apoptosis by regulating cell cycle proteins in H1299 cells XREF_BIBR."
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"PSMD14 knockdown induces cell cycle arrest , senescence and apoptosis by regulating cell cycle proteins in H1299 cells 30 ."
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"Knockdown of PSMD14 could facilitate cell apoptosis by increasing cleaved caspase-3 levels, and could cause G1 arrest and cellular senescence by increasing p21 stability in lung adenocarcinoma cells [39]."
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"Therefore, there could be an alternative pathway that involves in pRb, cyclin-CDK, CKIs and cyclin-CDK activators in cell cycle arrest and senescence induced by PSMD14 knockdown."
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"For example, siRNA targeting PSMD14 (Rpn11), which is part of the 19S cap of the proteasome, leads to cell cycle arrest and senescence as well as decreasing cyclin B1, cyclin D1 and phospho-Rb levels with1228Expert Opin."
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