IndraLab

Statements

USP22 activates Cyclin. 5 / 5
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"USP22 can stabilize cyclin D1 and promote the nuclear accumulation of cyclin D1 (16)."
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"An in vitro study showed that the upregulation of USP22 mediated the enhanced expression of BMI1 and Cyclin D2, and was responsible for increased cell proliferation and the metastatic behavior of colon cancer cells ."
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"19 However, there has been a lack of thorough investigation into the role of USP22 in hepatocellular carcinoma development and Sorafenib resistance.In this study, we demonstrate that USP22 promotes the proliferation of hepatocellular carcinoma cells by stabilising cyclin‐dependent kinase 11B (CDK11B)."
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"Hence, USP22 overexpression was associated with reduced p21 and p27 levels and increased abundance of Cyclin D1, CDK4 and CDK6, which collectively form a complex that promotes G1 progression [XREF_BIBR]."
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"In addition, Usp22 promotes CRC by stabilizing cyclin B1."
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