IndraLab
Statements
reach
"To help elucidate which intracellular signalling pathways the K562 cell line and PMA-I stimulation of NK cells were acting through, additional functional assays were performed with immune cell inhibitor drugs LY294002 (inhibitor of Pi3K activity), PD98059 (inhibitor of MEK in MAPK pathway), Rapamycin (inhibitor of mTOR) and Rottlerin (inhibitor of PKC in the NFkB pathway)."
reach
"These included clinically used immunosuppressive drugs such as a calcineurin inhibitor (Cyclosporine A), an anti-proliferative agent (MPA) and a corticosteroid (Prednisolone), but also the additional intracellular signalling inhibitor drugs Rapamycin (inhibitor of mTOR), Rottlerin (inhibitor of PKC in the NFkB pathway), LY294002 (inhibitor of Pi3K activity) and PD98059 (inhibitor of MEK in MAPK pathway)."