IndraLab

Statements

AMPK inhibits KCNQ1. 7 / 10
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eidos
"Stimulation by alpha1-AR suppresses the Kv7.1 / KCNE1 current and triggers the ubiquitin-dependent CME by activating AMPK [ 14 ] ."
| PMC
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"AMPK activation decreased KCNQ1 currents and channel surface expression in X. laevis oocytes, but AMPK did not phosphorylate KCNQ1 in vitro, suggesting an indirect regulatory mechanism."
20861072
sparser
"Similar to ENaC, AMPK inhibits KCNQ1 via Nedd4-2, as demonstrated in collecting duct principal cells of rat ex vivo kidney slices [ xref ], MDCK cells [ xref ], and Xenopus oocytes [ xref ]."
30404151
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"These results may indicate that PKC activation is partly involved in the KCNQ1 internalization by α 1 AR activation.Because AMP-dependent protein kinase (AMPK) is reported to inhibit KCNQ1 activity th[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31491415
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"AMPK has previously been shown to down-regulate the epithelial Na + channel ENaC [40-43] and the K + channel KCNQ1 and KCNE1 [44], effects considered to be mediated by stimulation of the ubiquitin lig[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21501591
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"Previous study has, in fact, demonstrated that AMPK is a target downstream of PKC reducing Kv7.1 cell surface expression though activation of Nedd4-2 ( Andersen et al., 2012 )."
25796298
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"However, AMPK is known to contribute to hyperpolarizing shifts in the voltage dependence of Nav1.5, decreased amplitudes of BK , TASK, and TREK channel currents, and decreased membrane expression of Kv7.1 and Kir2.1 channels [5],all effects that would presumably enhance cellular activity."
23831352