IndraLab

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Mutated KCNH2 inhibits Kr. 4 / 4
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"K897T was previously associated with a prolonged QT interval in several different populations and can alter the biophysical properties of mutant channels (current density, activation, inactivation, and recovery from inactivation) and exacerbate the I Kr reduction caused by other KCNH2 mutations [XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR, XREF_BIBR]."
28749435
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"26 In this particular case, it was possible that reduced repolarization reserves due to enhanced I Kr inhibition caused by a combination of KCNH2 mutation, hypokalemia and oral garenoxacin contributed[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Most of hERG mutations underlying type 2 LQTS (LQTS2) suppress I Kr currents by causing trafficking defects XREF_BIBR, XREF_BIBR."
30258187
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"HERG mutations resulting in reduced I Kr cause type 2 long QT syndrome (LQT2), which predisposes individuals to life threatening arrhythmias."
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