IndraLab

Statements

Double-stranded RNA inhibits OAS1. 3 / 3
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eidos
"These studies reveal that binding orientation-specific activation also exists in solution and that OAS1 activation by short dsRNAs is unexpectedly sensitive to both RNA sequence and the relative organization of activating motifs ."
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"To better understand these drivers of OAS activation , we tested the impact of defined sequence changes within a short dsRNA that strongly activates OAS1 ."
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"Here , the requirements for OAS1 activation by short dsRNAs are explored further using variations on this model 18 bp dsRNA ."
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