IndraLab

Statements

Mutated BAP1 activates Melanoma. 5 / 5
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"In melanoma, BAP1 mutations promote tumor cell glycolysis, leading to increased lactate production."
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"Whereas BAP1 mutations drive BAP1 tumour predisposition syndrome, mesotheliomas, melanomas and other neoplasms 8–11 ; ASXL1 mutations are particularly prevalent in myeloid cancers, and are associated [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Germline BAP1 mutations cause mesothelioma and other malignancies, namely, uveal cancer, meningioma, and melanoma, overall defined as “BAP1- related cancer syndrome”."
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"BAP1 mutations cause prevalently mesothelioma and melanomas."
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"Moreover, in uveal melanoma, somatic BAP1 mutations cause metastasis with a probability of 74%, while the same has been observed in only 36% of the patients carrying a germline mutation [104]."
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